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ICSI with microinjection of morphologically selected sperm

One of the most innovative techniques in the world of human fertility is the IMSI, or microinjection of morphologically selected spermatozoa.

What is IMSI?

This test is known by the English acronym MSOME (Motile Sperm Organelle Morphology Examination). The oocyte micro-injection of spermatozoa selected with this high-resolution optical system is known as IMSI.

The IMSI allows injecting the oocytes only with selected spermatozoa according to strict morphological criteria in which the size, shape of the head, the middle part of the sperm, and the presence of vacuoles in the head are considered.

A correlation has been established between large vacuoles in the sperm head and DNA fragmentation. It is thus believed that the IMSI “deselects” spermatozoa with physiological abnormalities associated with DNA fragmentation. Therefore, up to 68% of “normal” spermatozoa selected to be injected under a lesser optical resolution do not meet the criteria for selection of IMSI.

A recent meta-analysis showed that the use of IMSI significantly increases the percentage of embryonic implantation (OR 2.72; 95% CI 1.50-4.95) and pregnancy (OR 3.12; 95% CI 1.55-6.26) and reduces the risk of abortion (OR 0.42; 95% CI 0.23-0.78) in comparison with ICSI. Randomized studies have also shown that couples with failed ICSI cycles associated with poor sperm quality achieve term pregnancies after IMSI.

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